An efficient enantioselective synthesis of (R)-selegiline has been achieved by two routes, via proline-catalyzed α-aminooxylation as well as α-amination of phenylpropanaldehyde as the key step.
Bibliographical noteFunding Information:
S.K.T. thanks CSIR, New Delhi, for financial support. The authors thank Dr. B. D. Kulkarni, Head, CE-PD Division, for his constant encouragement and support.
Copyright 2008 Elsevier B.V., All rights reserved.
- Asymmetric reactions