An orally bioavailable (Mice) prodrug of glutathione

Daune L. Crankshaw; Jacquie E. Briggs; Robert Vince; Herbert T. Nagasawa

doi:10.3390/antiox10060939

An orally bioavailable (Mice) prodrug of glutathione

Daune L. Crankshaw, Jacquie E. Briggs, Robert Vince, Herbert T. Nagasawa

Research output: Contribution to journal › Article › peer-review

Abstract

L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

Original language	English (US)
Article number	939
Journal	Antioxidants
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/antiox10060939
State	Published - Jun 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the Dept of Veterans Affairs, Minneapolis, MN, and the Center for Drug Design, University of Minnesota.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Bioavailable
Glutathione
Orally
Prodrug

PubMed: MeSH publication types

Journal Article

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10.3390/antiox10060939

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abstract = "L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.",

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note = "Funding Information: Funding: This research was funded by the Dept of Veterans Affairs, Minneapolis, MN, and the Center for Drug Design, University of Minnesota. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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language = "English (US)",

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AU - Briggs, Jacquie E.

AU - Vince, Robert

AU - Nagasawa, Herbert T.

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N2 - L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

AB - L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

KW - Bioavailable

KW - Glutathione

KW - Orally

KW - Prodrug

UR - https://www.scopus.com/pages/publications/85107494491

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VL - 10

JO - Antioxidants

JF - Antioxidants

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M1 - 939

ER -

An orally bioavailable (Mice) prodrug of glutathione

Abstract

Bibliographical note

Keywords

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