L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.
Bibliographical noteFunding Information:
Funding: This research was funded by the Dept of Veterans Affairs, Minneapolis, MN, and the Center for Drug Design, University of Minnesota.
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