An orally bioavailable (Mice) prodrug of glutathione

Daune L. Crankshaw, Jacquie E. Briggs, Robert Vince, Herbert T. Nagasawa

Research output: Contribution to journalArticlepeer-review


L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

Original languageEnglish (US)
Article number939
Issue number6
StatePublished - Jun 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the Dept of Veterans Affairs, Minneapolis, MN, and the Center for Drug Design, University of Minnesota.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Bioavailable
  • Glutathione
  • Orally
  • Prodrug

PubMed: MeSH publication types

  • Journal Article


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