An old idea tackling a new problem: Targeted toxins specific for cancer stem cells

Nate N. Waldron; Daniel A. Vallera

doi:10.3390/antib2010082

An old idea tackling a new problem: Targeted toxins specific for cancer stem cells

Nate N. Waldron, Daniel A. Vallera

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse.

Original language	English (US)
Pages (from-to)	82-92
Number of pages	11
Journal	Antibodies
Volume	2
Issue number	1
DOIs	https://doi.org/10.3390/antib2010082
State	Published - Jan 28 2013

Keywords

Cancer stem cells
CD123
CD133
CD44
EpCAM
Immunotoxins
Targeted toxins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antib2010082

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title = "An old idea tackling a new problem: Targeted toxins specific for cancer stem cells",

abstract = "Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse.",

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AB - Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse.

KW - Cancer stem cells

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KW - CD133

KW - CD44

KW - EpCAM

KW - Immunotoxins

KW - Targeted toxins

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ER -

An old idea tackling a new problem: Targeted toxins specific for cancer stem cells

Abstract

Keywords

UN SDGs

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