An official American Thoracic Society Workshop Report

Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness

Eleanor M. Summerhill, Gary W. Hoyle, Sven Eric Jordt, Bronwen J. Jugg, James G. Martin, Sadis Matalon, Steven Patterson, David J. Prezant, Alfred M. Sciuto, Erik R. Svendsen, Carl W. White, Livia A. Veress

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This report is based on the proceedings from the Inhalational Lung InjuryWorkshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental,Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectiveswere to (1) provide a forumto review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.

Original languageEnglish (US)
Pages (from-to)1060-1072
Number of pages13
JournalAnnals of the American Thoracic Society
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2017

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Irritants
Lung Injury
Disasters
Phosgene
Mustard Gas
Terrorism
Education
Bromine
Lung
Chlorine
National Institutes of Health (U.S.)
Cyanides
Occupational Health
Dust
Research
Epidemiology
Thorax
Gases
Therapeutics
Population

Cite this

An official American Thoracic Society Workshop Report : Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness. / Summerhill, Eleanor M.; Hoyle, Gary W.; Jordt, Sven Eric; Jugg, Bronwen J.; Martin, James G.; Matalon, Sadis; Patterson, Steven; Prezant, David J.; Sciuto, Alfred M.; Svendsen, Erik R.; White, Carl W.; Veress, Livia A.

In: Annals of the American Thoracic Society, Vol. 14, No. 6, 01.06.2017, p. 1060-1072.

Research output: Contribution to journalArticle

Summerhill, EM, Hoyle, GW, Jordt, SE, Jugg, BJ, Martin, JG, Matalon, S, Patterson, S, Prezant, DJ, Sciuto, AM, Svendsen, ER, White, CW & Veress, LA 2017, 'An official American Thoracic Society Workshop Report: Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness', Annals of the American Thoracic Society, vol. 14, no. 6, pp. 1060-1072. https://doi.org/10.1513/AnnalsATS.201704-297WS
Summerhill, Eleanor M. ; Hoyle, Gary W. ; Jordt, Sven Eric ; Jugg, Bronwen J. ; Martin, James G. ; Matalon, Sadis ; Patterson, Steven ; Prezant, David J. ; Sciuto, Alfred M. ; Svendsen, Erik R. ; White, Carl W. ; Veress, Livia A. / An official American Thoracic Society Workshop Report : Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness. In: Annals of the American Thoracic Society. 2017 ; Vol. 14, No. 6. pp. 1060-1072.
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