An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: Biomonitoring

Geary W. Olsen, Perry W. Logan, Kristen J. Hansen, Cathy A. Simpson, Jean M. Burris, Michele M. Burlew, Phanasouk P. Vorarath, Pothapragad Venkateswarlu, John C. Schumpert, Jeffrey H. Mandel

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


This investigation randomly sampled a fluorochemical manufacturing employee population to determine the distribution of serum fluorochemical levels according to employees’ jobs and work areas. Previous analyses of medical surveillance data have not shown significant associations between fluorochemical production employees’ clinical chemistry and hematology tests and their serum PFOS and perfluorooctanoate (PFOA, C7F15COO2) concentrations, but may have been subject to nonparticipation bias. A random sample of the on-site film plant employee population, where fluorochemicals are not produced, determined their serum concentrations also. Of the 232 employees randomly selected for serum sampling, 186 (80%) employees participated (n5126 chemical plant; n560 film plant). Sera samples were extracted using an ion-pairing extraction procedure and were quantitatively analyzed for seven fluorochemicals using high-pressure liquid chromatography electrospray tandem mass spectrometry methods. Geometric means (in parts per million) and 95% confidence intervals (in parentheses) of the random sample of 126 chemical plant employees were: PFOS 0.941 (0.787-1.126); PFOA 0.899 (0.722-1.120); perfluorohexanesulfonate 0.180 (0.145-0.223); Nethyl perfluorooctanesulfonamidoacetate 0.008 (0.006-0.011); N-methyl perfluorooctanesulfonamidoacetate 0.081 (0.067-0.098); perfluorooctanesulfonamide 0.013 (0.009-0.018); and perfluorooctanesulfonamidoacetate 0.022 (0.018-0.029). These geometric means were approximately one order of magnitude higher than those observed for the film plant employees.

Original languageEnglish (US)
Pages (from-to)651-629
Number of pages23
JournalAmerican Industrial Hygiene Association Journal
Issue number5
StatePublished - Sep 2003
Externally publishedYes


  • Biological monitoring
  • Fluorochemicals
  • Organic fluorine
  • Perfluorooctanesulfonate
  • Perfluorooctanoate


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