We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2×10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
|Original language||English (US)|
|Number of pages||6|
|Journal||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics|
|State||Published - Oct 1 2010|
Bibliographical notePublisher Copyright:
© 2010 Wiley-Liss, Inc.
- Bipolar disorder