An integrated view of β-cell dysfunction in type-II diabetes

Vincent Poitout, R. Paul Robertson

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Type-II (non-insulin-dependent) diabetes mellitus (NIDDM) is a heterogeneous disease resulting from insulin resistance and β-cell dysfunction. β-Cell dysfunction in Type-II diabetes is characterized by a specific lack of first-phase glucose-induced insulin secretion. This defect is readily reversible upon normalization of blood glucose levels. Chronic hyperglycemia itself is harmful to the β-cell and affects both insulin biosynthesis and exocytosis. No unique intracellular defect has been demonstrated to be responsible for all common forms of the disease. However, mutations of the glucokinase gene have been identified in maturity onset diabetes in the young, a particular form of NIDDM.

Original languageEnglish (US)
Pages (from-to)69-83
Number of pages15
JournalAnnual review of medicine
StatePublished - 1996


  • Insulin secretion
  • Non-insulin-dependent diabetes
  • Pancreatic β-cell


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