An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Keyphrases

• Small Molecules 100%
• High-throughput Screening 100%
• Screening Approach 100%
• TNF Receptor 1 (TNFR1) 100%
• Ligand Binding 40%
• Zafirlukast 40%
• Triclabendazole 40%
• Living Cells 20%
• Fluorescence Lifetime 20%
• High-throughput 20%
• Receptor-ligand Interaction 20%
• Autoimmune Disease 20%
• Adverse Effects 20%
• Oligomeric 20%
• Spatial Resolution 20%
• Temporal Resolution 20%
• Inflammatory Response 20%
• Receptor Activation 20%
• Inflammatory Diseases 20%
• Sequester 20%
• Current Treatment 20%
• NF-B 20%
• Tumor Necrosis Factor-α 20%
• Membrane Receptors 20%
• Screening Platform 20%
• Free Ligand 20%
• Computational Docking 20%
• Docking Technique 20%
• Lymphotoxin 20%
• TNFR Superfamily 20%
• FRET Biosensor 20%
• Pre-ligand Assembly Domain 20%
• Small Molecule Compounds 20%
• Target Receptor 20%

Pharmacology, Toxicology and Pharmaceutical Science

• High-Throughput Screening 100%
• Receptor 100%
• Tumor Necrosis Factor Receptor 100%
• Tumor Necrosis Factor Receptor 1 80%
• Zafirlukast 40%
• Tumor Necrosis Factor 40%
• Triclabendazole 40%
• Inflammatory Disease 20%
• Side Effect 20%
• Lymphotoxin 20%
• Inflammation 20%
• Autoimmune Disease 20%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• High Throughput Screening 100%
• Tumor Necrosis Factor Receptor 100%
• Ligand Binding 40%
• Zafirlukast 40%
• Tumor Necrosis Factor 40%
• Fluorescence Resonance Energy Transfer 20%
• Lifespan 20%
• Upregulation 20%
• Transmembrane Receptors 20%
• Tumor Necrosis Factor Alpha 20%
• Lymphotoxin 20%
• Lymphotoxin Alpha 20%