An increase in chromogranin A-positive, hormone-negative endocrine cells in pancreas in cystic fibrosis

Megan Cory, Abu Saleh Md Moin, Antoinette Moran, Robert A. Rizza, Peter C. Butler, Sangeeta Dhawan, Alexandra E. Butler

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We sought to establish whether an increase in chromogranin A-positive, hormone-negative (CPHN) endocrine cells occurs in the pancreas of patients with cystic fibrosis (CF), as potential evidence of neogenesis. Pancreata were obtained at autopsy from nondiabetic patients with CF (n = 12) and age-matched nondiabetic control subject (CS) individuals without CF (n = 12). In addition, pancreas from three diabetic patients with CF was obtained. Pancreas sections were stained for chromogranin A, insulin, and a cocktail of glucagon, somatostatin, pancreatic polypeptide, and ghrelin and evaluated for the frequency of CPHN cells. There was a higher frequency of CPHN cells in islets of the patients with CF compared with the CS group. Moreover, CPHN cells occurring as single cells or clusters scattered in the exocrine pancreas were also more frequent in patients with CF. The increased frequency of CPHN cells in pancreas of patients with CF may indicate an attempt at endocrine cell regeneration.

Original languageEnglish (US)
Pages (from-to)1058-1066
Number of pages9
JournalJournal of the Endocrine Society
Volume2
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • Cystic fibrosis
  • Inflammation
  • β cell

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