The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - Jul 9 2001|
- NNN and NNKOAc
- Tobacco-specific nitrosamines