An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Lisa A Peterson, Thomas E. Spratt, Weifeng Shan, Lijuan Wang, Witold Subotkowski, Robert Roth

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume44
Issue number6
DOIs
StatePublished - Jul 9 2001

Keywords

  • NNK
  • NNN and NNKOAc
  • Tobacco-specific nitrosamines

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