An Improved Oil Emulsion Synthesis Method for Large, Porous Zirconia Particles for Packed- or Fluidized-Bed Protein Chromatography

Michael J. Robichaud, Arun N. Sathyagal, Peter W. Carr, Alon V. McCormick, Michael C. Flickinger

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A previously reported oil emulsion technique for the synthesis of large, porous zirconia particles has been modified to overcome problems of nonreproducibility, formation of non-spherical or broken particles, and low yield of chromatographically useful particles. The improved technique described here uses a concentrated sol and an in-line mixer to successfully solve these problems. The results indicate that the stirring rate used to maintain the emulsion during drying has a strong effect on the final particle size.

Original languageEnglish (US)
Pages (from-to)2547-2559
Number of pages13
JournalSeparation Science and Technology
Volume32
Issue number15
DOIs
StatePublished - Jan 1 1997

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