An improved method of oxazolidinone hydrolysis in the asymmetric synthesis of α-alkylprolines

Michael J. Genin, Paul W. Baures, Rodney L. Johnson

Research output: Contribution to journalArticlepeer-review

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Abstract

An improvement in Seebach's method for the synthesis of α-alkylprolines is reported wherein the hydrolysis of the chiral oxazolidinone 2 is performed on a suspension of silica gel in MeOH/H2O. Following hydrolysis, the pure α-alkylproline can be obtained by filtration thereby avoiding a tedious ion exchange purification.

Original languageEnglish (US)
Pages (from-to)4967-4968
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number28
DOIs
StatePublished - Jul 11 1994

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