An improved large scale procedure for the preparation of N-Cbz amino acids

Ashok D. Pehere, Andrew D. Abell

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A simple and scalable method for the preparation of N-Cbz protected amino acids is presented which uses a mixture of aqueous sodium carbonate and sodium bicarbonate to maintain the appropriate pH during the addition of benzyl chloroformate. The method has been extended to other N-protections and is amenable to large scale preparation of an intermediate toward Zofenopril, an ACE inhibitor.

Original languageEnglish (US)
Pages (from-to)1493-1494
Number of pages2
JournalTetrahedron Letters
Volume52
Issue number13
DOIs
StatePublished - Mar 30 2011

Keywords

  • Large scale
  • N-Cbz amino acids
  • Synthesis
  • Zofenopril

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