An extract of agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo

Jaung Geng Lin, Ming Jen Fan, Nou Ying Tang, Jai Sing Yang, Te Chun Hsia, Jen Jyh Lin, Kuang Chi Lai, Rick Sai-Chuen Wu, Chia Yu Ma, W. Gibson Wood, Jing Gung Chung

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Purpose. The edible mushroom (fungus) Agaricus blazei Murill (ABM) is a health food in many countries. Importantly, it has been shown to have antitumor and immune effects. There is no available information on ABM-affected immune responses in leukemia mice in vivo. Experimental Design. In this study, the authors investigated the immunopotentiating activities of boiled water-soluble extracts from desiccated ABM in WEHI-3 leukemia mice. The major characteristic of WEHI-3 leukemia mice are enlarged spleens and livers after intraperitoneal injection with murine leukemia WEHI-3 cells. Isolated T cells from spleens of ABM-treated mice resulted in increased T-cell proliferation compared with the untreated control with concanavalin A stimulation. Results. ABM decreased the spleen and liver weights when compared with WEHI-3 leukemia mice and this effect was a dose-dependent response. ABM promoted natural killer cell activity and phagocytosis by macrophage/monocytes in leukemia mice in a dose-dependent manner. ABM also enhanced cytokines such as interleukin (IL)-1β, IL-6, and interferon-γ levels but reduced the level of IL-4 in WEHI-3 leukemia mice. Moreover, ABM increased the levels of CD3 and CD19 but decreased the levels of Mac-3 and CD11b in leukemia mice. Conclusions. The ABM extract is likely to stimulate immunocytes and regulate immune response in leukemia mice in vivo.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalIntegrative Cancer Therapies
Volume11
Issue number1
DOIs
StatePublished - Mar 2012

Bibliographical note

Funding Information:
This study was supported by Grant CMU-96-073 from China Medical University, Taichung, Taiwan, and Grant DOH99-TDC-111-005 from Department of Health, Executive Yuan, ROC (Taiwan).

Keywords

  • Agaricus blazei Murill extract
  • NK cells
  • WEHI-3 cells
  • immune responses
  • leukemia BALB/c mice
  • phagocytosis

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