An explanation for the controlled release of macromolecules from polymers

Rajan Bawa; Ronald A. Siegel; Brian Marasca; Marcus Karel; Robert Langer

doi:10.1016/0168-3659(85)90002-1

An explanation for the controlled release of macromolecules from polymers

Rajan Bawa, Ronald A. Siegel, Brian Marasca, Marcus Karel, Robert Langer

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Controlled release systems composed of hydrophobic polymers such as ethylene-vinyl acetate copolymer have proven useful for releasing various polypeptides and other macromolecules for over 100 days. However, the release mechanism has never been elucidated. Evidence by microscopy is presented suggesting that release occurs through interconnecting pores formed by the macromolecules themselves. A mathematical model has been developed and used to predict the release rates of different proteins.

Original language	English (US)
Pages (from-to)	259-267
Number of pages	9
Journal	Journal of Controlled Release
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0168-3659(85)90002-1
State	Published - Jun 1985

Bibliographical note

Funding Information:
This work was supported by NIH grant GM26698. We thank Dean Hsieh and Andrew Braunstein for assistance.

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10.1016/0168-3659(85)90002-1

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title = "An explanation for the controlled release of macromolecules from polymers",

abstract = "Controlled release systems composed of hydrophobic polymers such as ethylene-vinyl acetate copolymer have proven useful for releasing various polypeptides and other macromolecules for over 100 days. However, the release mechanism has never been elucidated. Evidence by microscopy is presented suggesting that release occurs through interconnecting pores formed by the macromolecules themselves. A mathematical model has been developed and used to predict the release rates of different proteins.",

author = "Rajan Bawa and {A. Siegel}, Ronald and Brian Marasca and Marcus Karel and Robert Langer",

note = "Funding Information: This work was supported by NIH grant GM26698. We thank Dean Hsieh and Andrew Braunstein for assistance.",

year = "1985",

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T1 - An explanation for the controlled release of macromolecules from polymers

AU - Bawa, Rajan

AU - A. Siegel, Ronald

AU - Marasca, Brian

AU - Karel, Marcus

AU - Langer, Robert

N1 - Funding Information: This work was supported by NIH grant GM26698. We thank Dean Hsieh and Andrew Braunstein for assistance.

PY - 1985/6

Y1 - 1985/6

N2 - Controlled release systems composed of hydrophobic polymers such as ethylene-vinyl acetate copolymer have proven useful for releasing various polypeptides and other macromolecules for over 100 days. However, the release mechanism has never been elucidated. Evidence by microscopy is presented suggesting that release occurs through interconnecting pores formed by the macromolecules themselves. A mathematical model has been developed and used to predict the release rates of different proteins.

AB - Controlled release systems composed of hydrophobic polymers such as ethylene-vinyl acetate copolymer have proven useful for releasing various polypeptides and other macromolecules for over 100 days. However, the release mechanism has never been elucidated. Evidence by microscopy is presented suggesting that release occurs through interconnecting pores formed by the macromolecules themselves. A mathematical model has been developed and used to predict the release rates of different proteins.

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U2 - 10.1016/0168-3659(85)90002-1

DO - 10.1016/0168-3659(85)90002-1

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 4

ER -

An explanation for the controlled release of macromolecules from polymers

Abstract

Bibliographical note

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