An explanation for the controlled release of macromolecules from polymers

Rajan Bawa, Ronald A. Siegel, Brian Marasca, Marcus Karel, Robert Langer

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Controlled release systems composed of hydrophobic polymers such as ethylene-vinyl acetate copolymer have proven useful for releasing various polypeptides and other macromolecules for over 100 days. However, the release mechanism has never been elucidated. Evidence by microscopy is presented suggesting that release occurs through interconnecting pores formed by the macromolecules themselves. A mathematical model has been developed and used to predict the release rates of different proteins.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalJournal of Controlled Release
Volume1
Issue number4
DOIs
StatePublished - Jun 1985

Bibliographical note

Funding Information:
This work was supported by NIH grant GM26698. We thank Dean Hsieh and Andrew Braunstein for assistance.

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