An experimental study of nanoparticle focusing with aerodynamic lenses

Xiaoliang Wang, Peter H McMurry

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


High sampling efficiencies of analyte ions, molecules or particles are needed to maximize the sensitivity of mass spectrometers. "Ion funnels", which utilize electrodynamic focusing, have been shown to effectively focus ions with mass-to-charge ratio (m/z) ranging from ∼100 to 5000. Focusing efficiencies of ion funnels drop for higher m/z values because very high voltages are needed to overcome the particle inertia. Conventional "aerodynamic lenses" utilize inertia to focus down to 25 nm in diameter (∼5 MDa); to date, Brownian diffusion has prevented the effective focusing of particles smaller than this. We recently reported a design procedure that should, in principle, extend focusing with aerodynamic lenses to particles as small as 3 nm (∼10 kDa), thereby bridging the gap between the ion funnel and the conventional aerodynamic lenses. In this paper, we report for the first time experimental results for the performance of these new "nanolenses". Measurements were done using spherical oil droplets, proteins, and sodium chloride particles ranging in size from 3 to 30 nm diameter. We found that particle transport efficiencies from atmospheric pressure to vacuum through the aerodynamic lens system were greater than 80% for 10-30 nm particles, and greater than 50% for a ∼3.8 nm protein (Lysozyme from chicken egg white, molecular weight 14.3 kDa). Particle beam diameters were about a factor of two greater than predicted by our numerical simulations, but provide clear evidence that the nanolenses effectively focus all three particle types.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalInternational Journal of Mass Spectrometry
Issue number1-3
StatePublished - Dec 1 2006

Bibliographical note

Funding Information:
This work was supported by NSF (Grant No. DMI-0103169). We thank Dr. Hiromu Sakurai for his advice on a suitable solvent and buffer solution for electrospraying the vacuum pump oil.


  • Aerodynamic lens
  • Electrospray
  • Focusing
  • Nanoparticle
  • Particle beam
  • Transmission efficiency


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