Abstract
Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.
| Original language | English (US) |
|---|---|
| Article number | e1010958 |
| Journal | Molecular and Cellular Oncology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2016 |
Bibliographical note
Publisher Copyright:© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- RUBICON
- UVRAG
- autophagy
- endosome
- lysosome
- mTOR
- mTORC1
Fingerprint
Dive into the research topics of 'An expanded role for mTORC1 in autophagy'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS