An expanded role for mTORC1 in autophagy

Young Mi Kim; Ji Man Park; Douglas Grunwald; Do Hyung Kim

doi:10.1080/23723556.2015.1010958

An expanded role for mTORC1 in autophagy

Young Mi Kim, Ji Man Park, Douglas Grunwald, Do Hyung Kim

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

Original language	English (US)
Article number	e1010958
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1010958
State	Published - Jan 2 2016

Bibliographical note

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.

Keywords

RUBICON
UVRAG
autophagy
endosome
lysosome
mTOR
mTORC1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1010958

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title = "An expanded role for mTORC1 in autophagy",

abstract = "Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.",

keywords = "RUBICON, UVRAG, autophagy, endosome, lysosome, mTOR, mTORC1",

author = "Kim, \{Young Mi\} and Park, \{Ji Man\} and Douglas Grunwald and Kim, \{Do Hyung\}",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2016, {\textcopyright} Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.",

year = "2016",

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doi = "10.1080/23723556.2015.1010958",

language = "English (US)",

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T1 - An expanded role for mTORC1 in autophagy

AU - Kim, Young Mi

AU - Park, Ji Man

AU - Grunwald, Douglas

AU - Kim, Do Hyung

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

AB - Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

KW - RUBICON

KW - UVRAG

KW - autophagy

KW - endosome

KW - lysosome

KW - mTOR

KW - mTORC1

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UR - https://www.scopus.com/inward/citedby.url?scp=85026467655&partnerID=8YFLogxK

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DO - 10.1080/23723556.2015.1010958

M3 - Article

AN - SCOPUS:85026467655

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - e1010958

ER -

An expanded role for mTORC1 in autophagy

Abstract

Bibliographical note

Keywords

UN SDGs

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