An expanded role for mTORC1 in autophagy

Young Mi Kim, Ji Man Park, Douglas Grunwald, Do Hyung Kim

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9 Scopus citations


Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

Original languageEnglish (US)
Article numbere1010958
JournalMolecular and Cellular Oncology
Issue number1
StatePublished - Jan 2 2016

Bibliographical note

Funding Information:
This study was supported by grants from the National Institutes of Health (P30- DK050456, GM097057, AG039758), U.S. Department of Defense (W81XWH- 13-1-0060), and American Diabetes Asso ciation (ADA 7-12-BS-093).

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.


  • autophagy
  • endosome
  • lysosome
  • mTOR
  • mTORC1


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