An expanded role for mTORC1 in autophagy

Young Mi Kim, Ji Man Park, Douglas Grunwald, Do Hyung Kim

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

Original languageEnglish (US)
Article numbere1010958
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • RUBICON
  • UVRAG
  • autophagy
  • endosome
  • lysosome
  • mTOR
  • mTORC1

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