TY - JOUR
T1 - An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons
AU - Slaughter, Malcolm M.
AU - Miller, Robert F.
PY - 1983
Y1 - 1983
N2 - cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.
AB - cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.
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U2 - 10.1126/science.6131536
DO - 10.1126/science.6131536
M3 - Article
C2 - 6131536
AN - SCOPUS:0020673429
SN - 0036-8075
VL - 219
SP - 1230
EP - 1232
JO - Science
JF - Science
IS - 4589
ER -