An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Elizabeth B. Hirsch; Kai Tai Chang; Paola C. Zucchi; Dennis N. Francoeur; Kimberly R. Ledesma; Vincent H. Tamb; Todd M. Lasco

doi:10.1016/j.jiac.2013.10.011

An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Elizabeth B. Hirsch
, Kai Tai Chang
, Paola C. Zucchi
, Dennis N. Francoeur
, Kimberly R. Ledesma
, Vincent H. Tamb
, Todd M. Lasco

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

Original language	English (US)
Pages (from-to)	224-227
Number of pages	4
Journal	Journal of Infection and Chemotherapy
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.jiac.2013.10.011
State	Published - Mar 2014
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund .

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CRE
Carbapenem
Chromogenic agar
Modified Hodge test
Phenylboronic acid

Publisher link

10.1016/j.jiac.2013.10.011

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title = "An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae",

abstract = "Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100\% sensitivity and specificity.",

keywords = "CRE, Carbapenem, Chromogenic agar, Modified Hodge test, Phenylboronic acid",

author = "Hirsch, \{Elizabeth B.\} and Chang, \{Kai Tai\} and Zucchi, \{Paola C.\} and Francoeur, \{Dennis N.\} and Ledesma, \{Kimberly R.\} and Tamb, \{Vincent H.\} and Lasco, \{Todd M.\}",

note = "Funding Information: This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund . ",

year = "2014",

month = mar,

doi = "10.1016/j.jiac.2013.10.011",

language = "English (US)",

volume = "20",

pages = "224--227",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

AU - Hirsch, Elizabeth B.

AU - Chang, Kai Tai

AU - Zucchi, Paola C.

AU - Francoeur, Dennis N.

AU - Ledesma, Kimberly R.

AU - Tamb, Vincent H.

AU - Lasco, Todd M.

N1 - Funding Information: This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund .

PY - 2014/3

Y1 - 2014/3

N2 - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

AB - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

KW - CRE

KW - Carbapenem

KW - Chromogenic agar

KW - Modified Hodge test

KW - Phenylboronic acid

UR - https://www.scopus.com/pages/publications/84903700813

UR - https://www.scopus.com/pages/publications/84903700813#tab=citedBy

U2 - 10.1016/j.jiac.2013.10.011

DO - 10.1016/j.jiac.2013.10.011

M3 - Article

C2 - 24674388

AN - SCOPUS:84903700813

SN - 1341-321X

VL - 20

SP - 224

EP - 227

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 3

ER -

An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Abstract

Bibliographical note

UN SDGs

Keywords

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