Abstract
Twenty-one patients were treated with actinomycin D and 22 with mitomycin C. The principal toxic effects of actinomycin D were ulceration of the mouth and pharynx, nausea, and dermatitis, while the main toxic effect of mitomycin C was bone marrow depression. One patient with Hodgkin's disease improved with actinomycin D. Short improvement was found in a case of carcinoma of the pancreas and carcinoma of the esophagus with mitomycin C. Neither of these drugs is considered to have great value in the treatment of human malignancy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 881-885 |
| Number of pages | 5 |
| Journal | Surgery |
| Volume | 50 |
| Issue number | 6 |
| State | Published - Dec 1961 |
