An evaluation of actinomycin D and mitomycin C in patients with advanced cancer

Edward W. Humphrey, Alan C. Hymes, Robert K. Ausman, Donald J. Ferguson

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Abstract

Twenty-one patients were treated with actinomycin D and 22 with mitomycin C. The principal toxic effects of actinomycin D were ulceration of the mouth and pharynx, nausea, and dermatitis, while the main toxic effect of mitomycin C was bone marrow depression. One patient with Hodgkin's disease improved with actinomycin D. Short improvement was found in a case of carcinoma of the pancreas and carcinoma of the esophagus with mitomycin C. Neither of these drugs is considered to have great value in the treatment of human malignancy.

Original languageEnglish (US)
Pages (from-to)881-885
Number of pages5
JournalSurgery
Volume50
Issue number6
StatePublished - Dec 1 1961

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    Humphrey, E. W., Hymes, A. C., Ausman, R. K., & Ferguson, D. J. (1961). An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. Surgery, 50(6), 881-885.