Twenty-one patients were treated with actinomycin D and 22 with mitomycin C. The principal toxic effects of actinomycin D were ulceration of the mouth and pharynx, nausea, and dermatitis, while the main toxic effect of mitomycin C was bone marrow depression. One patient with Hodgkin's disease improved with actinomycin D. Short improvement was found in a case of carcinoma of the pancreas and carcinoma of the esophagus with mitomycin C. Neither of these drugs is considered to have great value in the treatment of human malignancy.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Dec 1 1961|