An evaluation of actinomycin D and mitomycin C in patients with advanced cancer

Edward W. Humphrey, Alan C. Hymes, Robert K. Ausman, Donald J. Ferguson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Twenty-one patients were treated with actinomycin D and 22 with mitomycin C. The principal toxic effects of actinomycin D were ulceration of the mouth and pharynx, nausea, and dermatitis, while the main toxic effect of mitomycin C was bone marrow depression. One patient with Hodgkin's disease improved with actinomycin D. Short improvement was found in a case of carcinoma of the pancreas and carcinoma of the esophagus with mitomycin C. Neither of these drugs is considered to have great value in the treatment of human malignancy.

Original languageEnglish (US)
Pages (from-to)881-885
Number of pages5
JournalSurgery
Volume50
Issue number6
StatePublished - Dec 1 1961

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Dilatation and Curettage
Dactinomycin
Mitomycin
Poisons
Carcinoma
Neoplasms
Dermatitis
Pharynx
Hodgkin Disease
Nausea
Esophagus
Mouth
Pancreas
Bone Marrow
Pharmaceutical Preparations
Therapeutics

Cite this

Humphrey, E. W., Hymes, A. C., Ausman, R. K., & Ferguson, D. J. (1961). An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. Surgery, 50(6), 881-885.

An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. / Humphrey, Edward W.; Hymes, Alan C.; Ausman, Robert K.; Ferguson, Donald J.

In: Surgery, Vol. 50, No. 6, 01.12.1961, p. 881-885.

Research output: Contribution to journalArticle

Humphrey, EW, Hymes, AC, Ausman, RK & Ferguson, DJ 1961, 'An evaluation of actinomycin D and mitomycin C in patients with advanced cancer', Surgery, vol. 50, no. 6, pp. 881-885.
Humphrey EW, Hymes AC, Ausman RK, Ferguson DJ. An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. Surgery. 1961 Dec 1;50(6):881-885.
Humphrey, Edward W. ; Hymes, Alan C. ; Ausman, Robert K. ; Ferguson, Donald J. / An evaluation of actinomycin D and mitomycin C in patients with advanced cancer. In: Surgery. 1961 ; Vol. 50, No. 6. pp. 881-885.
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