Abstract
Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31373-31376 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 11 |
| Issue number | 50 |
| DOIs | |
| State | Published - Sep 14 2021 |
Bibliographical note
Funding Information:We gratefully acknowledge the NIH (P01-CA234228) and the University of Minnesota for nancial support. Mass spectrometry was performed at the University of Minnesota Masonic Cancer Center Analytical Biochemistry Core Facility, which is supported by the NIH (P30-CA77598).
Publisher Copyright:
© 2021 The Royal Society of Chemistry.
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SDG 3 Good Health and Well-being
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