An efficient solid-phase synthesis of 3-carboxycoumarins based on a scaffold-polymerbound cyclic malonic ester

Jing Tang, Xian Huang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The condensation of substituted o-methoxybenzaldehydes or o-hydroxybenzaldehydes with a resin-bound cyclic malonic ester 3 afforded the resin 4 without catalyst. Cyclisation of the resin 4 in sulfuric acid formed 3-carboxycoumarins in good yield and excellent purity.

Original languageEnglish (US)
Pages (from-to)354-355
Number of pages2
JournalJournal of Chemical Research - Part S
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • 3-carboxycoumarins
  • O-methoxybenzaldehydes or o-hydroxybenzaldehydes
  • Resin-bound cyclic malonic acid ester

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