An early phase of instructive plasticity before the typical onset of sensory experience

Arani Roy, Shen Wang, Benyamin Meschede-Krasa, Jordan Breffle, Stephen D. Van Hooser

Research output: Contribution to journalArticle

Abstract

While early experience with moving stimuli is necessary for the development of direction selectivity in visual cortex of carnivores, it is unclear whether experience exerts a permissive or instructive influence. To test if the specific parameters of the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets were exposed to several hours of experience with unusual spatiotemporal patterns. In the most immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive influence. In animals that were 1–10 days more mature, exposure to the same patterns led to a developmentally-typical increase in direction selectivity. We conclude that visual development progresses via an early phase of instructive plasticity, when the specific patterns of neural activity shape the specific parameters of the emerging response properties, followed by a late phase of permissive maturation, when sensory-driven activity merely serves to enhance the response properties already seeded in cortical circuits.

Original languageEnglish (US)
Article number11
JournalNature communications
Volume11
Issue number1
DOIs
StatePublished - Dec 1 2020
Externally publishedYes

Fingerprint

Ferrets
plastic properties
Plasticity
selectivity
Visual Cortex
stimuli
Neurons
Animals
Networks (circuits)
cortexes
neurons
animals
emerging
Direction compound

PubMed: MeSH publication types

  • Journal Article

Cite this

An early phase of instructive plasticity before the typical onset of sensory experience. / Roy, Arani; Wang, Shen; Meschede-Krasa, Benyamin; Breffle, Jordan; Van Hooser, Stephen D.

In: Nature communications, Vol. 11, No. 1, 11, 01.12.2020.

Research output: Contribution to journalArticle

Roy, Arani ; Wang, Shen ; Meschede-Krasa, Benyamin ; Breffle, Jordan ; Van Hooser, Stephen D. / An early phase of instructive plasticity before the typical onset of sensory experience. In: Nature communications. 2020 ; Vol. 11, No. 1.
@article{14fc20ba5a4543fea71815f79de19f6e,
title = "An early phase of instructive plasticity before the typical onset of sensory experience",
abstract = "While early experience with moving stimuli is necessary for the development of direction selectivity in visual cortex of carnivores, it is unclear whether experience exerts a permissive or instructive influence. To test if the specific parameters of the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets were exposed to several hours of experience with unusual spatiotemporal patterns. In the most immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive influence. In animals that were 1–10 days more mature, exposure to the same patterns led to a developmentally-typical increase in direction selectivity. We conclude that visual development progresses via an early phase of instructive plasticity, when the specific patterns of neural activity shape the specific parameters of the emerging response properties, followed by a late phase of permissive maturation, when sensory-driven activity merely serves to enhance the response properties already seeded in cortical circuits.",
author = "Arani Roy and Shen Wang and Benyamin Meschede-Krasa and Jordan Breffle and {Van Hooser}, {Stephen D.}",
year = "2020",
month = "12",
day = "1",
doi = "10.1038/s41467-019-13872-1",
language = "English (US)",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - An early phase of instructive plasticity before the typical onset of sensory experience

AU - Roy, Arani

AU - Wang, Shen

AU - Meschede-Krasa, Benyamin

AU - Breffle, Jordan

AU - Van Hooser, Stephen D.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - While early experience with moving stimuli is necessary for the development of direction selectivity in visual cortex of carnivores, it is unclear whether experience exerts a permissive or instructive influence. To test if the specific parameters of the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets were exposed to several hours of experience with unusual spatiotemporal patterns. In the most immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive influence. In animals that were 1–10 days more mature, exposure to the same patterns led to a developmentally-typical increase in direction selectivity. We conclude that visual development progresses via an early phase of instructive plasticity, when the specific patterns of neural activity shape the specific parameters of the emerging response properties, followed by a late phase of permissive maturation, when sensory-driven activity merely serves to enhance the response properties already seeded in cortical circuits.

AB - While early experience with moving stimuli is necessary for the development of direction selectivity in visual cortex of carnivores, it is unclear whether experience exerts a permissive or instructive influence. To test if the specific parameters of the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets were exposed to several hours of experience with unusual spatiotemporal patterns. In the most immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive influence. In animals that were 1–10 days more mature, exposure to the same patterns led to a developmentally-typical increase in direction selectivity. We conclude that visual development progresses via an early phase of instructive plasticity, when the specific patterns of neural activity shape the specific parameters of the emerging response properties, followed by a late phase of permissive maturation, when sensory-driven activity merely serves to enhance the response properties already seeded in cortical circuits.

UR - http://www.scopus.com/inward/record.url?scp=85077430174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077430174&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-13872-1

DO - 10.1038/s41467-019-13872-1

M3 - Article

C2 - 31896763

AN - SCOPUS:85077430174

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 11

ER -