An autoradiographic study in μ-opioid receptor knockout mice

Hung Chun Chen, Virginia S. Seybold, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)170-172
Number of pages3
JournalMolecular Brain Research
Issue number1
StatePublished - Mar 10 2000

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health research grants DA00564, DA01583, DA11806, DA70554 and the F. and A. Stark Fund of the Minnesota Medical Foundation.


  • Autoradiography
  • Knock-out mice
  • Opioid receptor


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