An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.
Bibliographical noteFunding Information:
This research was supported by National Institutes of Health research grants DA00564, DA01583, DA11806, DA70554 and the F. and A. Stark Fund of the Minnesota Medical Foundation.
- Knock-out mice
- Opioid receptor