An autocatalytic network for ribozyme self-construction

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


The emergence of a primordial RNA world would have required the formation of RNA polymers of sufficient length to possess catalytic activities, which are difficult to obtain by spontaneous polymerization. An analysis of an autocatalytic assembly pathway that can self-construct a functioning ribozyme from smaller oligonucleotide building blocks describes a potential route for RNA extension.

Original languageEnglish (US)
Pages (from-to)654-655
Number of pages2
JournalNature Chemical Biology
Issue number11
StatePublished - Nov 2008


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