An Artificial Gut/Absorption Simulator: Understanding the Impact of Absorption on In Vitro Dissolution, Speciation, and Precipitation of Amorphous Solid Dispersions

Keyphrases

• Speciation 100%
• Amorphous Solid Dispersion 100%
• Gastric Absorption 100%
• In Vitro Dissolution 100%
• Artificial Gut 100%
• Free Drug 50%
• Bound Drug 50%
• Crystalline Precipitates 50%
• Ketoconazole 33%
• Hypromellose Acetate Succinate 33%
• Analytical Techniques 16%
• Testing Method 16%
• Mass Transfer 16%
• Hollow Fiber 16%
• Drug Loading 16%
• Solute 16%
• Supersaturated Solution 16%
• Operating Parameters 16%
• Rank Order 16%
• Fiber-based 16%
• Dissolution Test 16%
• Static Equilibrium 16%
• Solution Concentration 16%
• Multiple Processes 16%
• Dynamic Equilibrium 16%
• High Drug Loading 16%
• Dissolution Media 16%
• Polymeric Excipients 16%
• Drug Dissolution 16%
• BCS Class II 16%
• Physiological Rates 16%
• Drug Removal 16%
• Amorphous Precipitates 16%
• Dissolution Control 16%
• Bile Micelles 16%
• Poorly Water-soluble Drugs 16%
• Drug Solution 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Amorphous Solid Dispersion 100%
• Succinic Acid 33%
• Ketoconazole 33%
• Hydroxypropylmethylcellulose 33%
• Excipient 16%
• Micelle 16%