AN ANTI-FOULING AIRWAY STENT

Daniel Glumac; Koji Kadowaki; Roy Cho; Gregory Peterson; Ryan Hunter; Leslie Kent; Robroy MacIver; Vidhu Pandey; Kazuhiro Tanahashi

doi:10.1115/dmd2022-1031

AN ANTI-FOULING AIRWAY STENT

Daniel Glumac, Koji Kadowaki, Roy Cho, Gregory Peterson, Ryan Hunter, Leslie Kent, Robroy MacIver, Vidhu Pandey, Kazuhiro Tanahashi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.

Original language	English (US)
Title of host publication	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
Publisher	American Society of Mechanical Engineers
ISBN (Electronic)	9780791885710
DOIs	https://doi.org/10.1115/dmd2022-1031
State	Published - 2022
Event	2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States Duration: Apr 11 2022 → Apr 14 2022

Publication series

Name	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference	2022 Design of Medical Devices Conference, DMD 2022
Country/Territory	United States
City	Minneapolis, Virtual
Period	4/11/22 → 4/14/22

Bibliographical note

Funding Information:
Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs.

Funding Information:
This work was conducted in conjunction with the Earl E. Bakken Medical Devices Center (Institute of Engineering in Medicine at the University of Minnesota Medical School). Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Parts of this work were carried out in the Advanced Preclinical Imaging Center which is part of the Lillehei Heart Institute at the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. The authors also thank Experimental Surgical Services at the University of Minnesota for assistance with sample sterilization.

Funding Information:
Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919).

Publisher Copyright:
© 2022 by ASME

Keywords

airway stent
anti-fouling
mucus

Publisher link

10.1115/dmd2022-1031

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Cite this

Glumac, D., Kadowaki, K., Cho, R., Peterson, G., Hunter, R., Kent, L., MacIver, R., Pandey, V., & Tanahashi, K. (2022). AN ANTI-FOULING AIRWAY STENT. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T05A002 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/dmd2022-1031

AN ANTI-FOULING AIRWAY STENT. / Glumac, Daniel; Kadowaki, Koji; Cho, Roy et al.
Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. V001T05A002 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Glumac, D, Kadowaki, K, Cho, R, Peterson, G, Hunter, R, Kent, L, MacIver, R, Pandey, V & Tanahashi, K 2022, AN ANTI-FOULING AIRWAY STENT. in Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022., V001T05A002, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022, American Society of Mechanical Engineers, 2022 Design of Medical Devices Conference, DMD 2022, Minneapolis, Virtual, United States, 4/11/22. https://doi.org/10.1115/dmd2022-1031

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abstract = "Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.",

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note = "Funding Information: Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. Funding Information: This work was conducted in conjunction with the Earl E. Bakken Medical Devices Center (Institute of Engineering in Medicine at the University of Minnesota Medical School). Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Parts of this work were carried out in the Advanced Preclinical Imaging Center which is part of the Lillehei Heart Institute at the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. The authors also thank Experimental Surgical Services at the University of Minnesota for assistance with sample sterilization. Funding Information: Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Publisher Copyright: {\textcopyright} 2022 by ASME; 2022 Design of Medical Devices Conference, DMD 2022 ; Conference date: 11-04-2022 Through 14-04-2022",

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AU - Kent, Leslie

AU - MacIver, Robroy

AU - Pandey, Vidhu

AU - Tanahashi, Kazuhiro

N1 - Funding Information: Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. Funding Information: This work was conducted in conjunction with the Earl E. Bakken Medical Devices Center (Institute of Engineering in Medicine at the University of Minnesota Medical School). Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Parts of this work were carried out in the Advanced Preclinical Imaging Center which is part of the Lillehei Heart Institute at the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. The authors also thank Experimental Surgical Services at the University of Minnesota for assistance with sample sterilization. Funding Information: Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Publisher Copyright: © 2022 by ASME

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N2 - Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.

AB - Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.

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ER -

AN ANTI-FOULING AIRWAY STENT

Abstract

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Conference

Bibliographical note

Keywords

Publisher link

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