AN ANTI-FOULING AIRWAY STENT

Daniel Glumac, Koji Kadowaki, Roy Cho, Gregory Peterson, Ryan Hunter, Leslie Kent, Robroy MacIver, Vidhu Pandey, Kazuhiro Tanahashi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.

Original languageEnglish (US)
Title of host publicationProceedings of the 2022 Design of Medical Devices Conference, DMD 2022
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791885710
DOIs
StatePublished - 2022
Externally publishedYes
Event2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States
Duration: Apr 11 2022Apr 14 2022

Publication series

NameProceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference2022 Design of Medical Devices Conference, DMD 2022
Country/TerritoryUnited States
CityMinneapolis, Virtual
Period4/11/224/14/22

Bibliographical note

Funding Information:
Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs.

Funding Information:
This work was conducted in conjunction with the Earl E. Bakken Medical Devices Center (Institute of Engineering in Medicine at the University of Minnesota Medical School). Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919). Parts of this work were carried out in the Advanced Preclinical Imaging Center which is part of the Lillehei Heart Institute at the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the NSF through the MRSEC (Award Number DMR-2011401) and the NNCI (Award Number ECCS-2025124) programs. The authors also thank Experimental Surgical Services at the University of Minnesota for assistance with sample sterilization.

Funding Information:
Mucin and microbiological analyses were performed in the Hunter laboratory which receives partial support from the National Heart Lung and Blood Institute (Award Number 1R01HL136919).

Publisher Copyright:
© 2022 by ASME

Keywords

  • airway stent
  • anti-fouling
  • mucus

Fingerprint

Dive into the research topics of 'AN ANTI-FOULING AIRWAY STENT'. Together they form a unique fingerprint.

Cite this