An analysis of the effects of galanin on gastric acid secretion and plasma levels of gastrin in the dog

Giulio Soldani, Grazia Mengozzi, Augusto Della Longa, Luigi Intorre, Franco Martelli, David Robert Brown

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28 Scopus citations

Abstract

The effects of galanin on gastric acid secretion and plasma levels of gastrin were studied in conscious dogs chronically fitted with gastric fistulas. Continuous i.v. infusion of galanin (2 μg · kg-1 · h-) for 2 h did not affect unstimulated total acid output or plasma levels of gastrin. In contrast, simultaneous i.v. infusion of galanin (1-2 μg · kg-1 · h-1) inhibited the bombesin-stimulated output of acid whereas the effects of bombesin on gastrin output were not significantly modified. Galanin (2-4 μg · kg-1 i.v.) also depressed the secretory response to 2-deoxy-D-glucose without significantly affecting plasma gastrin levels. Galanin (2-4 μg · kg-1 i.v.) did not depress bethanechol-stimulated gastric acid output or inhibit histamine-stimulated gastric acid secretion. These findings indicate that galanin inhibits the bombesin- and 2-deoxy-D-glucose-stimulated secretion of gastric acid in conscious dogs by an action which is probably exerted at the level of the cholinergic nerve terminals.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalEuropean Journal of Pharmacology
Volume154
Issue number3
DOIs
StatePublished - Sep 23 1988

Bibliographical note

Funding Information:
The authors are grateful to Mr Bruno Stacchini for his valuable technical assistance. The study was supported by a grant (No. CTB 87.00231.04) from the Consiglio Nazionale delle Ricerche (C.N.R.), Rome, Italy.

Keywords

  • (Dog)
  • Galanin
  • Gastric acid secretion
  • Gastrin (plasma)

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