An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival

Gudmundur Jóhann Arason; Sigurdur Bödvarsson; Sigurdur Por Sigurdarson; Gardar Sigurdsson; Gudmundur Porgeirsson; Sveinn Gudmundsson; Judit Kramer; Georg Füst

doi:10.1196/annals.1299.091

An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival

Gudmundur Jóhann Arason
, Sigurdur Bödvarsson
, Sigurdur Por Sigurdarson
, Gardar Sigurdsson
, Gudmundur Porgeirsson
, Sveinn Gudmundsson
, Judit Kramer
, Georg Füst

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.

Original language	English (US)
Pages (from-to)	496-499
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	1010
DOIs	https://doi.org/10.1196/annals.1299.091
State	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C4B*Q0
Coronary artery disease
Hungary
Iceland

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10.1196/annals.1299.091

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T1 - An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival

AU - Arason, Gudmundur Jóhann

AU - Bödvarsson, Sigurdur

AU - Sigurdarson, Sigurdur Por

AU - Sigurdsson, Gardar

AU - Porgeirsson, Gudmundur

AU - Gudmundsson, Sveinn

AU - Kramer, Judit

AU - Füst, Georg

PY - 2003

Y1 - 2003

N2 - We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.

AB - We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.

KW - C4BQ0

KW - Coronary artery disease

KW - Hungary

KW - Iceland

UR - https://www.scopus.com/pages/publications/1442356465

UR - https://www.scopus.com/pages/publications/1442356465#tab=citedBy

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AN - SCOPUS:1442356465

SN - 0077-8923

VL - 1010

SP - 496

EP - 499

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival

Abstract

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