TY - JOUR
T1 - An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival
AU - Arason, Gudmundur Jóhann
AU - Bödvarsson, Sigurdur
AU - Sigurdarson, Sigurdur Por
AU - Sigurdsson, Gardar
AU - Porgeirsson, Gudmundur
AU - Gudmundsson, Sveinn
AU - Kramer, Judit
AU - Füst, Georg
PY - 2003
Y1 - 2003
N2 - We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.
AB - We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.
KW - C4BQ0
KW - Coronary artery disease
KW - Hungary
KW - Iceland
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U2 - 10.1196/annals.1299.091
DO - 10.1196/annals.1299.091
M3 - Article
C2 - 15033778
AN - SCOPUS:1442356465
SN - 0077-8923
VL - 1010
SP - 496
EP - 499
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -
