An Acyclic Puromycin Analog. 6-Dimethylamino-9-[2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl]punne^†

In a continuation of our studies on nonglycosyl puromycin analogs, 6-dimethylamino-9-[2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl]purine was synthesized and separated into its two diastereoisomers. The lack of antimicrobial activity of this acyclic puromycin analog when compared with the previously prepared carbocyclic analog is discussed in terms of possible conformational requirements for ribosomal binding.