An Acyclic Puromycin Analog. 6-Dimethylamino-9-[2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl]punne

Robert Vince, Raymond G. Isakson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In a continuation of our studies on nonglycosyl puromycin analogs, 6-dimethylamino-9-[2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl]purine was synthesized and separated into its two diastereoisomers. The lack of antimicrobial activity of this acyclic puromycin analog when compared with the previously prepared carbocyclic analog is discussed in terms of possible conformational requirements for ribosomal binding.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalJournal of Medicinal Chemistry
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1973

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Puromycin
6-dimethylamino-9-(2-hydroxy-3-(4-methoxyphenyl-L- alanylamino)propyl)purine

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An Acyclic Puromycin Analog. 6-Dimethylamino-9-[2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl]punne . / Vince, Robert; Isakson, Raymond G.

In: Journal of Medicinal Chemistry, Vol. 16, No. 1, 01.01.1973, p. 37-40.

Research output: Contribution to journalArticle

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