The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.
Bibliographical noteFunding Information:
We are grateful to members of the Artandi laboratory and to D. Herschlag for critical comments. This work was supported by NIH grants CA197563 and AG056575 (S.E.A.), GM122579 and GM102519 (R.D.), and HG004361 (H.Y.C.). C.M.R. was supported by MSTP Training Grant GM007365 and by a Gerald J. Lieberman Fellowship . L.C. was supported by a Stanford Cancer Institute 2018 Fellowship Award .
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- CAB box
- Cajal body
- H/ACA RNP
- RNA folding
- dyskeratosis congenital