An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M. Roake, Adam Freund, Pedro J. Batista, Siqi Tian, Yi A. Yin, Chandresh R. Gajera, Shengda Lin, Byron Lee, Matthew F. Pech, Andrew S. Venteicher, Rhiju Das, Howard Y. Chang, Steven E. Artandi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

Original languageEnglish (US)
Pages (from-to)218-230.e13
JournalCell
Volume174
Issue number1
DOIs
StatePublished - Jun 28 2018
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to members of the Artandi laboratory and to D. Herschlag for critical comments. This work was supported by NIH grants CA197563 and AG056575 (S.E.A.), GM122579 and GM102519 (R.D.), and HG004361 (H.Y.C.). C.M.R. was supported by MSTP Training Grant GM007365 and by a Gerald J. Lieberman Fellowship . L.C. was supported by a Stanford Cancer Institute 2018 Fellowship Award .

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • CAB box
  • CR4/5
  • Cajal body
  • H/ACA RNP
  • RNA folding
  • TCAB1
  • dyskeratosis congenital
  • icSHAPE
  • telomerase
  • telomere

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