Amyloid P component is not present in the glomerular basement membrane in Alport-type hereditary nephritis

T. Melvin, Y. Kim, A. F. Michael

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Serum amyloid P component (SAP) is a normal plasma glycoprotein immunochemically indistinguishable from amyloid P, a glycoprotein found in all tissue amyloid deposits. SAP has also been shown to be a constitutent of normal glomerular basement membrane (GBM). In this study the authors discovered a unique association between SAP and Goodpasture (GP) antigen. In those patients whose GBM lack GP antigen (those with Alport-type hereditary nephritis) SAP is also uniformly absent. Although the relationship between these two components is unknown, this association may provide clues to the abnormality of GBM in Alport-type hereditary nephritis.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalAmerican Journal of Pathology
Volume125
Issue number3
StatePublished - Dec 1 1986

Fingerprint Dive into the research topics of 'Amyloid P component is not present in the glomerular basement membrane in Alport-type hereditary nephritis'. Together they form a unique fingerprint.

Cite this