TY - JOUR
T1 - Amyloid in the pancreatic islets of the cougar (Felis concolor) is derived from islet amyloid polypeptide (IAPP)
AU - Johnson, Kenneth H.
AU - Wernsted, Christer
AU - O'Brien, Timothy D.
AU - Westermark, Per
PY - 1991
Y1 - 1991
N2 - 1. 1. Islet amyloid isolated from the pancreas of a 20-year-old cougar (Felis concolor) was dissolved and purified by gel permeation and reversed phase HPLC mino acid sequence analysis. 2. 2. N-Terminal amino acid sequence analysis of the purified protein revealed a primary structure (positions 1-28) identical to islet amyloid polypeptide (IAPP) from domesticated cats. 3. 3. IAPP from the cougar, like IAPP from the human and domesticated cat, incorporates an inherently amyloidogenic AILS sequence at positions 25-28.
AB - 1. 1. Islet amyloid isolated from the pancreas of a 20-year-old cougar (Felis concolor) was dissolved and purified by gel permeation and reversed phase HPLC mino acid sequence analysis. 2. 2. N-Terminal amino acid sequence analysis of the purified protein revealed a primary structure (positions 1-28) identical to islet amyloid polypeptide (IAPP) from domesticated cats. 3. 3. IAPP from the cougar, like IAPP from the human and domesticated cat, incorporates an inherently amyloidogenic AILS sequence at positions 25-28.
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U2 - 10.1016/0305-0491(91)90316-6
DO - 10.1016/0305-0491(91)90316-6
M3 - Article
C2 - 2060275
AN - SCOPUS:0025966553
VL - 98
SP - 115
EP - 119
JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
SN - 0305-0491
IS - 1
ER -