Ampicillin‐Sulbactam versus Cefoxitin for Prophylaxis in High‐Risk Patients Undergoing Abdominal Surgery

Joseph A. Paladino, Miguel A. Rainstein, Deborah J. Serrianne, John E. Przylucki, Lynda S. Welage, Mario L. Collura, Jerome J. Schentag

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This double‐blind study compared ampicillin‐sulbactam 3 g versus cefoxitin 2 g in 136 adult patients at risk for developing an infection after abdominal surgery. Separate randomization schedules were used for colorectal, upper gastrointestinal/biliary, and other abdominal procedures. Study antibiotics were administered within 30 minutes before incision and repeated 6 hours later. Patients having colorectal surgery received a third dose of antibiotic 6 hours after the second. Efficacy evaluations were made on 123 patients, 62 in the ampicillin‐sulbactam group and 61 in the cefoxitin group. The overall postoperative infection rates were 12.9% for ampicillin‐sulbactam and 9.8% for cefoxitin (p>0.05); one wound infection occurred in each group. Adverse events were experienced by 13.2% of the ampicillin‐sulbactam and 19.1% of the cefoxitin recipients (p>0.05). Cost‐minimization analysis revealed that ampicillin‐sulbactam was a cost‐effective alternative to cefoxitin for the prevention of infection after abdominal surgery. 1994 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)734-739
Number of pages6
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number6
StatePublished - 1994


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