Amphetamine-induced alterations in the target enzymes: Possibility of a dual role in adaptation

Subhash C Basak, J. J. Ghosh

Research output: Contribution to journalArticle

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Abstract

Single d-amphetamine administration inhibited the specific activities of three membrane-bound enzymes from rat brain microsome viz. Na+-K+-Mg+2-ATPase, acetylcholinesterase (AchE) and glutamine synthetase (GS). A dichotomy was observed in the response of these enzymes to chronic drug treatment: Na+-K+-Mg+2-ATPase returned to control levels while AchE and GS activities showed significant increases. This paper proposed the idea that such dynamic reorientations might alleviate the initial drug action through 'localized scavenging' of the drug within the biophase. While higher amounts of AchE and GS are capable of binding more (as compared to acute) drug sparing, simultaneously, sufficient enzyme molecules for routine biological function, the desensitized form of Na+-K+-Mg+2-ATPase could have an augmented affinity for the drug molecule remaining, at the same time, unperturbed by drug binding. The realization of a teleological adaptive strategy within the framework of apparently diverse enzymatic responses is discussed with special reference to drug tolerance.

Original languageEnglish (US)
Pages (from-to)419-420
Number of pages2
JournalIRCS Medical Science
Volume10
Issue number5
StatePublished - Jan 1 1982

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Amphetamine
Glutamate-Ammonia Ligase
Enzymes
Acetylcholinesterase
Pharmaceutical Preparations
Drug Tolerance
Drug therapy
Dextroamphetamine
Molecules
Level control
Scavenging
Microsomes
Rats
Brain
Membranes
magnesium sodium potassium ATPase

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Amphetamine-induced alterations in the target enzymes : Possibility of a dual role in adaptation. / Basak, Subhash C; Ghosh, J. J.

In: IRCS Medical Science, Vol. 10, No. 5, 01.01.1982, p. 419-420.

Research output: Contribution to journalArticle

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