Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

Timothy W. Schacker; Cavan Reilly; Gregory J. Beilman; Jodie Taylor; David Skarda; David Krason; Matthew Larson; Ashley T. Haase

doi:10.1097/01.aids.0000194801.51422.03

Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

Timothy W. Schacker, Cavan Reilly, Gregory J. Beilman, Jodie Taylor, David Skarda, David Krason, Matthew Larson, Ashley T. Haase

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.

Original language	English (US)
Pages (from-to)	2169-2171
Number of pages	3
Journal	AIDS
Volume	19
Issue number	18
DOIs	https://doi.org/10.1097/01.aids.0000194801.51422.03
State	Published - Dec 2005

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abstract = "The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.",

author = "Schacker, {Timothy W.} and Cavan Reilly and Beilman, {Gregory J.} and Jodie Taylor and David Skarda and David Krason and Matthew Larson and Haase, {Ashley T.}",

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AU - Schacker, Timothy W.

AU - Reilly, Cavan

AU - Beilman, Gregory J.

AU - Taylor, Jodie

AU - Skarda, David

AU - Krason, David

AU - Larson, Matthew

AU - Haase, Ashley T.

PY - 2005/12

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AB - The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.

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Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

Abstract

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