Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

Timothy W. Schacker, Cavan Reilly, Gregory J. Beilman, Jodie Taylor, David Skarda, David Krason, Matthew Larson, Ashley T. Haase

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.

Original languageEnglish (US)
Pages (from-to)2169-2171
Number of pages3
JournalAIDS
Volume19
Issue number18
DOIs
StatePublished - Dec 2005

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