Abstract
Amino acid sequences of neurotoxins RTX-IV and RTX-V isolated from the sea anemone Radianthus macrodactylus were determined by the automated Edman degradation; their polypeptide chains consist of 48 and 47 amino acid residues, respectively. For identification of tryptophan-30 in toxin RTX-IV, its trypsin and chymotrypsin digests were investigated. Amino acid sequences of the above toxins show that they belong to a new structural class and that C-terminal positive charge and tyrosine-25 are important for toxic activity of sea anemone polypeptides.
| Translated title of the contribution | Amino acid sequence of neurotoxins IV and V from the sea anemone Radianthus macrodactylus |
|---|---|
| Original language | Russian |
| Pages (from-to) | 1489-1494 |
| Number of pages | 6 |
| Journal | Bioorganicheskaia khimiia |
| Volume | 14 |
| Issue number | 11 |
| State | Published - Nov 1 1988 |