Aminokislotnaia posledovatel'nost' neǐrotoksinov IV i V iz aktinii Radianthus macrodactylus.

Translated title of the contribution: Amino acid sequence of neurotoxins IV and V from the sea anemone Radianthus macrodactylus

Tatiana Zykova, E. P. Kozlovskaia, G. B. Eliakov

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Amino acid sequences of neurotoxins RTX-IV and RTX-V isolated from the sea anemone Radianthus macrodactylus were determined by the automated Edman degradation; their polypeptide chains consist of 48 and 47 amino acid residues, respectively. For identification of tryptophan-30 in toxin RTX-IV, its trypsin and chymotrypsin digests were investigated. Amino acid sequences of the above toxins show that they belong to a new structural class and that C-terminal positive charge and tyrosine-25 are important for toxic activity of sea anemone polypeptides.

Translated title of the contributionAmino acid sequence of neurotoxins IV and V from the sea anemone Radianthus macrodactylus
Original languageRussian
Pages (from-to)1489-1494
Number of pages6
JournalBioorganicheskaia khimiia
Volume14
Issue number11
StatePublished - Nov 1 1988

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