Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

E. J. McIntee, C. R. Wagner

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).

Original languageEnglish (US)
Pages (from-to)2803-2805
Number of pages3
JournalBioorganic & medicinal chemistry letters
Volume11
Issue number21
DOIs
StatePublished - Jan 1 2001

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Cytarabine
Nucleosides
Amino Acids
Substrates
Leukemia
Cells
Cell Line
Water
Growth
Serum
phosphoramidic acid
prostatic acid phosphatase
5-fluoro-2'-deoxyuridine

Cite this

Amino acid phosphoramidate nucleosides : potential ADEPT/GDEPT substrates. / McIntee, E. J.; Wagner, C. R.

In: Bioorganic & medicinal chemistry letters, Vol. 11, No. 21, 01.01.2001, p. 2803-2805.

Research output: Contribution to journal › Article

McIntee, EJ & Wagner, CR 2001, 'Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.', Bioorganic & medicinal chemistry letters, vol. 11, no. 21, pp. 2803-2805. https://doi.org/10.1016/S0960-894X(01)00513-3
McIntee EJ, Wagner CR. Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates. Bioorganic & medicinal chemistry letters. 2001 Jan 1;11(21):2803-2805. https://doi.org/10.1016/S0960-894X(01)00513-3
McIntee, E. J. ; Wagner, C. R. / Amino acid phosphoramidate nucleosides : potential ADEPT/GDEPT substrates. In: Bioorganic & medicinal chemistry letters. 2001 ; Vol. 11, No. 21. pp. 2803-2805.
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