Abstract
A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2803-2805 |
| Number of pages | 3 |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 11 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 5 2001 |
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McIntee, E. J., & Wagner, C. R. (2001). Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates. Bioorganic & medicinal chemistry letters, 11(21), 2803-2805. https://doi.org/10.1016/S0960-894X(01)00513-3