Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

E. J. McIntee, C. R. Wagner

Research output: Contribution to journalArticle

6 Scopus citations


A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).

Original languageEnglish (US)
Pages (from-to)2803-2805
Number of pages3
JournalBioorganic & medicinal chemistry letters
Issue number21
StatePublished - Nov 5 2001


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