Abstract
A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2803-2805 |
| Number of pages | 3 |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 11 |
| Issue number | 21 |
| DOIs | |
| State | Published - Jan 1 2001 |
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Amino acid phosphoramidate nucleosides : potential ADEPT/GDEPT substrates. / McIntee, E. J.; Wagner, C. R.
In: Bioorganic & medicinal chemistry letters, Vol. 11, No. 21, 01.01.2001, p. 2803-2805.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amino acid phosphoramidate nucleosides
T2 - potential ADEPT/GDEPT substrates.
AU - McIntee, E. J.
AU - Wagner, C. R.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
AB - A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
UR - http://www.scopus.com/inward/record.url?scp=0035814028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035814028&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)00513-3
DO - 10.1016/S0960-894X(01)00513-3
M3 - Article
VL - 11
SP - 2803
EP - 2805
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 21
ER -