Amikacin Therapy: Use Against Infections Caused by Gentamicin- and Tobramycin-Resistant Organisms

Victor L. Yu, Frank S. Rhame, Edward L. Pesanti, Stanton G. Axline

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Amikacin sulfate was used in 24 treatment courses for 25 serious infections caused by aerobic or facultative anaerobic Gram-negative organisms resistant to numerous drugs. Sites of infection included urinary tract (11 cases), pleuropulmonary (6 cases), primary bacteremia (5 cases), and miscellaneous (3 cases). Serratia marcescens and Pseudomonas sp accounted for 73% of the isolates. The mean minimal inhibitory concentration (MIC) of these organisms to amikacin was 3.6 μg/ml; to gentamicin, 39 μg/ml; and to tobramycin, 32 μg/ml. The mean peak serum concentration of the drug was 20.8 μg/ml. Eleven patients were critically ill at the onset of therapy, and seven patients were bacteremic. The overall favorable response rate was 80%. The most serious side effect was ototoxicity, which occurred in three of 15 patients examined by serial audiometry.

Original languageEnglish (US)
Pages (from-to)943-947
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume238
Issue number9
DOIs
StatePublished - Aug 29 1977
Externally publishedYes

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