Amidoacetone enolate anions: alkylation and Michael reaction

Thomas R. Hoye; Steven R. Duff; Rita S. King

doi:10.1016/S0040-4039(00)98657-X

Amidoacetone enolate anions: alkylation and Michael reaction

Thomas R. Hoye, Steven R. Duff, Rita S. King

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.

Original language	English (US)
Pages (from-to)	3433-3436
Number of pages	4
Journal	Tetrahedron Letters
Volume	26
Issue number	29
DOIs	https://doi.org/10.1016/S0040-4039(00)98657-X
State	Published - 1985

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title = "Amidoacetone enolate anions: alkylation and Michael reaction",

abstract = "The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.",

author = "Hoye, {Thomas R.} and Duff, {Steven R.} and King, {Rita S.}",

year = "1985",

doi = "10.1016/S0040-4039(00)98657-X",

language = "English (US)",

volume = "26",

pages = "3433--3436",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Amidoacetone enolate anions

T2 - alkylation and Michael reaction

AU - Hoye, Thomas R.

AU - Duff, Steven R.

AU - King, Rita S.

PY - 1985

Y1 - 1985

N2 - The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.

AB - The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.

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U2 - 10.1016/S0040-4039(00)98657-X

DO - 10.1016/S0040-4039(00)98657-X

M3 - Article

AN - SCOPUS:43049131026

VL - 26

SP - 3433

EP - 3436

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 29

ER -