Ameliorative effect of 1,2-benzenedicarboxylic acid dinonyl ester against amyloid β peptide-induced neurotoxicity

Soo Jung Choi, Mi Jeong Kim, Ho Jin Heo, Jae Kyeum Kim, Woo Jin Jun, Hye Kyung Kim, Eun Ki Kim, Myeong Ok Kim, Hong Yon Cho, Han Joon Hwang, Young Jun Kim, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Amyloid beta peptide (A)-induced oxidative stress may be linked to neurodegenerative disease. Ethanol extracts of Rosa laevigata protected PC12 cells from hydrogen peroxide-induced oxidative stress. (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide) reduction assays revealed a significant increase in cell viability when oxidatively stressed PC12 cells were treated with R. laevigata extract. The effect of R. laevigata on oxidative stress-induced cell death was further investigated by lactate dehydrogenase release assays and trypan blue exclusion assays. Administration of 1,2-benzenedicarboxylic acid dinonyl ester from R. laevigata extract to mice infused with A significantly reversed learning and memory impairment in behavioural tests. After behavioural testing, the mice were sacrificed and brains were collected for the examination of lipid peroxidation, catalase activity and acetylcholinesterase (AchE) activity. These results suggest that 1,2-benzenedicarboxylic acid dinonyl ester from R. laevigata extract may be able to reduce A-induced neurotoxicity, possibly by reducing oxidative stress. Therefore, R. laevigata extract may be useful for the prevention of oxidative stress-induced neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalAmyloid
Volume16
Issue number1
DOIs
StatePublished - Mar 2009

Keywords

  • A
  • Alzheimer's disease
  • Hydrogen peroxide
  • Oxidative stress
  • PC12 cells

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