Sixty-three women with suspected pelvic inflammatory disease were treated as outpatients with Augmentin with or without doxycycline. Initially, doxycycline was added only after a direct immunofluorescence test for Chlamydia trachomatis was positive. Because chlamydial infections were frequent, all patients received doxycycline during the last two thirds of the study. Neisseria gonorrhoeae or Chlamydia trachomatis were recovered from 15 (65%) of 23 women classified as probably having pelvic inflammatory disease. Among 47 women reexamined after starting therapy, three rapidly became worse and were hospitalized, nine (20%) discontinued therapy because of gastrointestinal side effects, and all of the remaining 35 women who completed therapy were either cured or improved.
Bibliographical noteFunding Information:
This work was supported fry Grant No. Al 12191 from the National Institutes of Health and by a grant from Beecham Laboratories.
- Chlamydia trachomatis
- Neisseria gonorrhoeae
- treatment of pelvic inflammatory disease