Ambulatory blood pressure monitoring for clinical applications and basic science

Germaine Cornelissen, Cathy Lee Gierke, Yoshihiko Watanabe, Larry A. Beaty, Jarmila Siegelova, Alain Delcourt, Christian Deruyck, Ram B. Singh, Miguel A. Revilla, Kuniaki Otsuka, BIOsphere and the COSmos (BIOCOS)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Monitoring for spans longer than 24 hours, preferably for 7 days at the outset, has been advocated to obtain more reliable estimates of the circadian characteristics of blood pressure and heart rate. Herein, using data from a chronotherapy trial, we address the desirability of complementing the global analysis of the entire record by the computation of daily sphygmochrons to gain a better assessment of the day-to-day variability in the circadian patterns of these variables. An algorithm for defining optimal spans covering approximately a day (while using all data in a record) is developed and implemented as a script in R. Combined with criteria to determine whether the data in a given span are sufficient to yield reliable estimates of the circadian characteristics of blood pressure and heart rate, results from this approach are compared by means of Bland-Altman plots to those stemming from considering 24-hour spans. Applications of daily sphygmochrons are wide-ranging, in patients as well as in healthy people, for clinical applications, for health maintenance and surveillance, for a better understanding of how blood pressure and heart rate are affected by a variety of factors in everyday life, such as nutrition, exercise, smoking, salt and alcohol intake, and for learning how human physiology is influenced by space-terrestrial weather.

Original languageEnglish (US)
Title of host publicationCurrent Trends in Cardiovascular Research
PublisherNova Science Publishers, Inc.
Pages111-124
Number of pages14
ISBN (Electronic)9781634856744
ISBN (Print)9781634856461
StatePublished - Jan 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Nova Science Publishers, Inc.

Keywords

  • Bland-altman plot
  • Circadian
  • Daily sphygmochrons
  • Day-to-day variability
  • Individualized chronotherapy
  • Vascular variability disorders (VVDs)

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