Amantadine-Resistant Influenza A in a Nursing Facility

John Degelau, Salma K. Somani, Susan L. Cooper, David R P Guay, Kent B. Crossley

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.

Original languageEnglish (US)
Pages (from-to)390-392
Number of pages3
JournalArchives of Internal Medicine
Issue number2
StatePublished - Feb 1992


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