Alzheimer's Disease: Transgenic Mouse Models

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transgenic mouse models of Alzheimer's disease (AD) have been created to study the structural and functional consequences of the accumulation of the amyloid-. ? and tau proteins in the brain. They have also been used to test experimental therapeutic interventions for AD. No transgenic mouse model perfectly represents all stages and facets of AD; transgenic mouse models cannot supplant the need for studying the disease in humans and human clinical trials. However, studies in transgenic mouse models allow researchers to understand aspects of the pathophysiology of AD and coordinate efforts to diagnose and treat the illness in humans.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages283-287
Number of pages5
ISBN (Print)9780080450469
DOIs
StatePublished - Dec 1 2010

Fingerprint

Transgenic Mice
Alzheimer Disease
tau Proteins
Amyloid
Research Personnel
Clinical Trials
Brain
Therapeutics

Cite this

Ashe, K. H. (2010). Alzheimer's Disease: Transgenic Mouse Models. In Encyclopedia of Neuroscience (pp. 283-287). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00546-5

Alzheimer's Disease : Transgenic Mouse Models. / Ashe, Karen H.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 283-287.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ashe, KH 2010, Alzheimer's Disease: Transgenic Mouse Models. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 283-287. https://doi.org/10.1016/B978-008045046-9.00546-5
Ashe KH. Alzheimer's Disease: Transgenic Mouse Models. In Encyclopedia of Neuroscience. Elsevier Ltd. 2010. p. 283-287 https://doi.org/10.1016/B978-008045046-9.00546-5
Ashe, Karen H. / Alzheimer's Disease : Transgenic Mouse Models. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 283-287
@inbook{418f70eb86db426ba7b79f94098a9289,
title = "Alzheimer's Disease: Transgenic Mouse Models",
abstract = "Transgenic mouse models of Alzheimer's disease (AD) have been created to study the structural and functional consequences of the accumulation of the amyloid-. ? and tau proteins in the brain. They have also been used to test experimental therapeutic interventions for AD. No transgenic mouse model perfectly represents all stages and facets of AD; transgenic mouse models cannot supplant the need for studying the disease in humans and human clinical trials. However, studies in transgenic mouse models allow researchers to understand aspects of the pathophysiology of AD and coordinate efforts to diagnose and treat the illness in humans.",
author = "Ashe, {Karen H}",
year = "2010",
month = "12",
day = "1",
doi = "10.1016/B978-008045046-9.00546-5",
language = "English (US)",
isbn = "9780080450469",
pages = "283--287",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Alzheimer's Disease

T2 - Transgenic Mouse Models

AU - Ashe, Karen H

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Transgenic mouse models of Alzheimer's disease (AD) have been created to study the structural and functional consequences of the accumulation of the amyloid-. ? and tau proteins in the brain. They have also been used to test experimental therapeutic interventions for AD. No transgenic mouse model perfectly represents all stages and facets of AD; transgenic mouse models cannot supplant the need for studying the disease in humans and human clinical trials. However, studies in transgenic mouse models allow researchers to understand aspects of the pathophysiology of AD and coordinate efforts to diagnose and treat the illness in humans.

AB - Transgenic mouse models of Alzheimer's disease (AD) have been created to study the structural and functional consequences of the accumulation of the amyloid-. ? and tau proteins in the brain. They have also been used to test experimental therapeutic interventions for AD. No transgenic mouse model perfectly represents all stages and facets of AD; transgenic mouse models cannot supplant the need for studying the disease in humans and human clinical trials. However, studies in transgenic mouse models allow researchers to understand aspects of the pathophysiology of AD and coordinate efforts to diagnose and treat the illness in humans.

UR - http://www.scopus.com/inward/record.url?scp=84882895384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882895384&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00546-5

DO - 10.1016/B978-008045046-9.00546-5

M3 - Chapter

AN - SCOPUS:84882895384

SN - 9780080450469

SP - 283

EP - 287

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -