Transgenic mouse models of Alzheimer's disease (AD) have been created to study the structural and functional consequences of the accumulation of the amyloid-. ? and tau proteins in the brain. They have also been used to test experimental therapeutic interventions for AD. No transgenic mouse model perfectly represents all stages and facets of AD; transgenic mouse models cannot supplant the need for studying the disease in humans and human clinical trials. However, studies in transgenic mouse models allow researchers to understand aspects of the pathophysiology of AD and coordinate efforts to diagnose and treat the illness in humans.