Alu retrotransposons and COVID-19 susceptibility and morbidity

Research output: Contribution to journalReview articlepeer-review

Abstract

SARS-CoV-2 has spread rapidly across the world and is negatively impacting the global human population. COVID-19 patients display a wide variety of symptoms and clinical outcomes, including those attributed to genetic ancestry. Alu retrotransposons have played an important role in human evolution, and their variants influence host response to viral infection. Intronic Alus regulate gene expression through several mechanisms, including both genetic and epigenetic pathways. With respect to SARS-CoV-2, an intronic Alu within the ACE gene is hypothesized to be associated with COVID-19 susceptibility and morbidity. Here, we review specific Alu polymorphisms that are of particular interest when considering host response to SARS-CoV-2 infection, especially polymorphic Alu insertions in genes associated with immune response and coagulation/fibrinolysis cascade. We posit that additional research focused on Alu-related pathways could yield novel biomarkers capable of predicting clinical outcomes as well as patient-specific treatment strategies for COVID-19 and related infectious diseases.

Original languageEnglish (US)
Article number2
Pages (from-to)2
JournalHuman Genomics
Volume15
Issue number1
DOIs
StatePublished - Jan 4 2021

Bibliographical note

Funding Information:
We thank the University of Minnesota COVID-19 Rapid Response Clinical Grants program for funding provided to ML and PAL in support of ongoing molecular research focused on the mechanisms reviewed herein. Dr. Roxanne Larsen provided helpful comments that improved this manuscript. Figs. and were created with BioRender ( https://biorender.com/ ).

Publisher Copyright:
© 2020, The Author(s).

Keywords

  • ACE
  • COVID-19
  • F13B
  • Human evolution
  • PGR
  • PLAT
  • SARS-CoV-2

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